KYZATREX Direct Program
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KYZATREX Direct Program
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Frequently Asked Questions

Please reach us at info@mariuspharma.com if you cannot find an answer to your question.

You need a prescription from a doctor for KYZATREX. You can visit www.kyzatrexdirect.com to order after receiving a prescription. 


KYZATREX (testosterone undecanoate) is an oral testosterone replacement treatment, made for men who have low or no testosterone due to certain medical conditions and prefer oral capsules to other methods of replacing testosterone. 


KYZATREX has a unique formulation which has produced differentiated efficacy and safety profiles. 


 KYZATREX is lymphatically absorbed and metabolized in your body into testosterone. 


Men 18 years and older who have low or no testosterone due to certain medical conditions. KYZATREX is not indicated for use in women or transgender men.  


In a clinical study of 139 men with low testosterone, 96% had normal testosterone levels at Day 90.*


*End of clinical study completers


KYZATREX's safety profile is similar to that of other testosterone replacement therapies. It has not demonstrated harmful effects on the liver. Since it is an oral option, it avoids the many of the other issues and concerns associated with other types of testosterone therapies, such as injections, pellets, and gels. 


KYZATREX is easy and convenient to take on the go. Store KYZATREX in a dry place at room temperature 68°F to 77°F (20°C to 25°C). Keep KYZATREX and all other medications out of the reach of children. 


KYZATREX should be taken twice a day with food - in the morning and then again in the evening - to help keep your testosterone levels balanced.


Missing a dose is fine. Skip your missed dose and take next scheduled dose at your usual time. Don't take two doses at once.


In a clinical study, KYZATREX raised testosterone levels to the normal range in 96% of adult men who completed 90 days of treatment.


KYZATREX may cause serious side effects, including increase in blood pressure; increase in red blood cell count or hemoglobin; worsening signs and symptoms of pre-existing enlarged prostate; increased risk of prostate cancer; blood clots in the legs or lungs. In large doses, KYZATREX may lower your sperm count; cause liver problems; cause swelling of ankles, feet, or body, with or without heart failure; cause enlarged or painful breasts; and cause breathing problems while you sleep.


In the MRS-TU-2019EXT study, the most common side effect with KYZATREX (incidence ≥2%) was hypertension (2.6%).


KYZATREX is a self-pay product, which is available for as little as $159 per month.


KYZATREX ORdering Questions

It is the pharmacy enrollment portal which allows the patient to provide all the required information, documentation, and payment to receive KYZATREX.


The pharmacy will maintain your information on file thereby eliminating new enrollment. However, you will be required to login to make changes and approve payment.


The pharmacy is strictly mail order. Medication ships out on Mondays through Wednesdays via second day delivery (with the exception of holidays). We strongly recommend refills are ordered prior to end of current supply. 


As a controlled substance, federal/state regulations do require signature upon receipt. 


Depending on regulations, some states allow prescriptions to be written with refills while others do not. Please check with your provider. 


The shipping address must match that of the government-issued identification provided on the enrollment portal. 


While the medication is reasonably protected during shipment, severely damaged boxes should not be accepted from the carrier. 


Log into your account on the enrollment portal to locate the tracking information.


Please call the pharmacy at 888-994-1950.


KYZATREX Direct

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